{"id":346,"date":"2021-06-09T14:15:30","date_gmt":"2021-06-09T12:15:30","guid":{"rendered":"https:\/\/2dchem.org\/?p=346"},"modified":"2021-06-09T14:21:54","modified_gmt":"2021-06-09T12:21:54","slug":"olomouc-scientists-developed-a-new-way-to-prevent-bacterial-resistance","status":"publish","type":"post","link":"https:\/\/2dchem.org\/index.php\/2021\/06\/09\/olomouc-scientists-developed-a-new-way-to-prevent-bacterial-resistance\/","title":{"rendered":"Olomouc scientists developed a new way to prevent bacterial resistance"},"content":{"rendered":"[vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” column_border_width=”none” column_border_style=”solid” bg_image_animation=”none”][vc_column_text]Scientists from Palack\u00fd University developed a new way to overcome bacteria\u2019s resistance to silver nanoparticles, which are commonly used in medicine for their antimicrobial effect. \u00a0A graphene derivative\u2014cyanographene\u2014played a major role this time round as the silver nanoparticles were bound to it by a solid bond. The scientists created a mechanical barrier that bacteria cannot overcome and therefore the effect of nanosilver is not reduced . This method has great potential in fighting harmful pathogens, particularly in local disinfection and antibacterial therapy.\u00a0The work entitled\u00a0Silver Covalently Bound to Cyanographene Overcomes Bacterial Resistance to Silver Nanoparticles and Antibiotics<\/a><\/em><\/strong>\u00a0was published in Advanced Science, and made it to the cover. \u00a0<\/strong><\/p>\n

The use of silver nanoparticles in modern medicine, where they support or partially replace \u00a0antibiotic treatment, has progressively increased mainly due to the dramatically growing resistance of bacteria to antibiotics. Three years ago, Olomouc scientists as part of their breakthrough discovery reported that bacteria can also build resistance to nanosilver. They found that silver nanoparticles lose their antibacterial effect when they cluster into larger units\u2014aggregates. Bacteria can attack this weak point of nanosilver by secreting a protein called flagellin, which makes the silver particles cluster into these aggregates and therefore lose their antibacterial properties. In order to solve this problem, UP scientists used chemically modified graphene.<\/p>\n

Strong bonds form an impermeable barrier<\/strong><\/p>\n

\u201cWe managed to form such a strong bond between the chemical groups on the graphene surface and the silver nanoparticles that even the bacteria\u2019s resistance mechanism cannot overcome. This is what makes the process so unique. We did not have to use any other chemicals, just the mechanical barrier,\u201d said the first author of the paper David Pan\u00e1\u010dek from the Czech Advanced Research and Technology Institute (CATRIN).<\/p>\n

Thanks to calculations and simulations conducted by theoretical chemists, the scientists identified and described how the material destroys a particular bacterium by severely damaging its membrane. \u201cWe have also demonstrated that our material can be used for a wide range of bacteria that are resistant to commonly used antibiotics,\u201d added David Pan\u00e1\u010dek.<\/p>\n

This new route is universal<\/strong><\/p>\n

In the past, UP scientists circumvented the resistance mechanism of bacteria by using natural substances. They published their work in the prestigious journal\u00a0Nature Nanotechnology<\/em>\u00a0in 2018. At that time, they added pomegranate extracts to the silver nanoparticles, blocking the production of flagellin. This was how the aggregates of particles were prevented and bacterial resistance overcome.<\/p>\n

\u201cThe advantage of the current solution is that the binding of nanosilver anchored to cyanographene is strong enough that the bacterial flagellin fail to make the silver nanoparticles cluster and they thus retain their high antibacterial activity. This universal approach will be effective even if bacteria manage to develop a different mechanism for nanoparticle aggregation by other chemicals than flagellin,\u201d said Ale\u0161 Pan\u00e1\u010dek from the Department of Physical Chemistry of the Faculty of Science, Palack\u00fd University.<\/p>\n

Contribution to solving the antibiotic resistance crisis<\/strong><\/p>\n

Antibacterial products, as we know them in contemporary medicine, have been used for almost 80 years. Yet bacterial infections are still a major problem whose importance is\u00a0 continuoulsy increasing. Current medicine is even confronted with the real threat of losing the effect of antibiotics on bacteria and the associated ability to treat bacterial infections.<\/p>\n

\u201cThis implies, among other things, the need to develop new and fully original antibacterial products. With this research, I believe our team is opening the door to tackling the issue of bacterial resistance to antibiotics and maintaining the ability to continue to treat bacterial infections. Equally important is the ability of the developed material to prevent infections related to artificial materials in the human body, which is important for example in the case of artificial heart valves or joint replacements. Of course, further research is needed to enable practical applications in clinical medicine,\u201d said Milan Kol\u00e1\u0159 from the Institute of Microbiology of the Faculty of Medicine and Dentistry and the University Hospital Olomouc<\/p>\n

Silver nanoparticles are used in medicine, for example, to disinfect medical instruments, with the antimicrobial effects being used for wound or burns dressings. Scientists are also considering the possibility of adding very small amounts of nanosilver to antibiotics, thus enhancing their effects and alleviating the problem of bacterial resistance to these drugs.<\/p>\n

\u201cAnchored nanoparticles exhibit higher efficacy than commonly used nanosilver, while being non-toxic to human cells. In addition, the solid anchoring of nanosilver with a chemical bond prevents its eventual release into the body. We see the potential of the developed material especially in local antibacterial therapy as part of covering materials or healing creams and ointments,\u201d concluded Radek Zbo\u0159il from CATRIN.[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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